Synonyms: 5alpha-Tetrahydrocorticosterone | allotetrahydrocorticosterone
Compound class:
Synthetic organic
Comment: 5α-tetrahydrocorticosterone (5αTHB) is an endogenous steroid with anti-inflammatory action [2]. In in vivo studies topically applied 5αTHB was less angiostatic and caused less skin thinning than the endogenous glucocorticoid/mineralocorticoid receptor agonists cortisol and corticosterone. It is proposed that 5αTHB's anti-inflammatory effects are mediated by mechanisms that are distinct from those of conventional glucocorticoids [1].
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References |
1. Abernethie AJ, Gastaldello A, Maltese G, Morgan RA, McInnes KJ, Small GR, Walker BR, Livingstone DE, Hadoke PW, Andrew R. (2022)
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids. Eur J Pharmacol, 929: 175111. [PMID:35738450] |
2. Gastaldello A, Livingstone DE, Abernethie AJ, Tsang N, Walker BR, Hadoke PW, Andrew R. (2017)
Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models. Biochem Pharmacol, 129: 73-84. [PMID:28131845] |