GTP-14564   Click here for help

GtoPdb Ligand ID: 5982

Compound class: Synthetic organic
Comment: GTP-14564 is a reversible, and ATP-competitive inhibitor of class III receptor tyrosine kinases [3].
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.82
Molecular weight 234.08
XLogP 4.39
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES c1ccc(cc1)c1n[nH]c2c1oc1c2cccc1
Isomeric SMILES c1ccc(cc1)c1n[nH]c2c1oc1c2cccc1
InChI InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17)

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
fms related receptor tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 12.1 6.0 0.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 36.1
mitogen-activated protein kinase kinase kinase kinase 5 nd/KHS(MAP4K5) Hs Inhibitor Inhibition 36.6
KIT proto-oncogene, receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 38.0 16.0 1.0
neurotrophic receptor tyrosine kinase 3 nd/TRKC Hs Inhibitor Inhibition 42.7
platelet derived growth factor receptor beta PDGFRβ/PDGFRb Hs Inhibitor Inhibition 44.9 50.0 9.0
serine/threonine kinase 3 MST2/MST2(STK3) Hs Inhibitor Inhibition 49.6 101.0 57.0
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 50.8 39.0 4.0
mitogen-activated protein kinase kinase kinase kinase 2 GCK/GCK(MAP4K2) Hs Inhibitor Inhibition 61.8 84.0 30.0
neurotrophic receptor tyrosine kinase 2 TrkB/TRKB Hs Inhibitor Inhibition 64.0 45.0 -3.0
Displaying the top 10 targets  View all targets in screen »