GTP-14564   Click here for help

GtoPdb Ligand ID: 5982

Compound class: Synthetic organic
Comment: GTP-14564 is a reversible, and ATP-competitive inhibitor of class III receptor tyrosine kinases [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.82
Molecular weight 234.08
XLogP 4.39
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES c1ccc(cc1)c1n[nH]c2c1oc1c2cccc1
Isomeric SMILES c1ccc(cc1)c1n[nH]c2c1oc1c2cccc1
InChI InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17)
InChI Key DZQLVVLATXPWBK-UHFFFAOYSA-N
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
KIT proto-oncogene, receptor tyrosine kinase Primary target of this compound Hs Inhibitor Inhibition 6.5 pIC50 - 3
pIC50 6.5 (IC50 3x10-7 M) [3]
colony stimulating factor 1 receptor Primary target of this compound Hs Inhibitor Inhibition 6.5 pIC50 - 3
pIC50 6.5 (IC50 3x10-7 M) [3]
fms related receptor tyrosine kinase 3 Primary target of this compound Hs Inhibitor Inhibition 6.5 pIC50 - 3
pIC50 6.5 (IC50 3x10-7 M) [3]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 6.0 pIC50 - 3
pIC50 6.0 (IC50 1x10-6 M) [3]