DNA-PK inhibitor V   Click here for help

GtoPdb Ligand ID: 5961

Synonyms: AMA37 | arylmorpholine analog 37
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 49.77
Molecular weight 283.12
XLogP 3.53
No. Lipinski's rules broken 0
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Canonical SMILES Oc1cc(ccc1C(=O)c1ccccc1)N1CCOCC1
Isomeric SMILES Oc1cc(ccc1C(=O)c1ccccc1)N1CCOCC1
InChI InChI=1S/C17H17NO3/c19-16-12-14(18-8-10-21-11-9-18)6-7-15(16)17(20)13-4-2-1-3-5-13/h1-7,12,19H,8-11H2

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C eta PKCη/PKCeta Hs Inhibitor Inhibition 70.0 116.0 83.0
mitogen-activated protein kinase kinase kinase 14 nd/NIK(MAP3K14) Hs Inhibitor Inhibition 75.1
mitogen-activated protein kinase 10 JNK3/JNK3 Hs Inhibitor Inhibition 75.3 83.0 53.0
LIM domain kinase 1 LIMK1/LIMK1 Hs Inhibitor Inhibition 83.9 105.0 80.0
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 84.2 102.0 103.0
protein kinase C zeta PKCζ/PKCzeta Hs Inhibitor Inhibition 85.0 97.0 104.0
dual serine/threonine and tyrosine protein kinase nd/RIPK5 Hs Inhibitor Inhibition 86.2
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 86.4
Protein kinase G (PKG) 1 PKG1β/PKG1b Hs Inhibitor Inhibition 86.8 93.0 80.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 89.0 86.0 68.0
Displaying the top 10 targets  View all targets in screen »