CXCL16   Click here for help

GtoPdb Ligand ID: 855

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXC chemokine ligand (CXCL) 16 is a ligand for chemokine receptor CXCR6. Once cleaved from the cell membrane CXCL16 acts as a chemoattractant for activated CD8 T cells, NKT cells and Th1-polarized T cells that express CXCR6.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Tohyama M, Sayama K, Komatsuzawa H, Hanakawa Y, Shirakata Y, Dai X, Yang L, Tokumaru S, Nagai H, Hirakawa S et al.. (2007)
CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes.
Int Immunol, 19 (9): 1095-102. [PMID:17855433]
2. Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M. (2001)
Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines.
J Immunol, 166 (8): 5145-54. [PMID:11290797]