CCL2   Click here for help

GtoPdb Ligand ID: 771

Immunopharmacology Ligand
Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
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1. Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN. (1997)
Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.
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A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
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Glycosylation enhances functional stability of the chemotactic cytokine CCL2.
Eur Cytokine Netw, 14 (2): 91-6. [PMID:12957789]
9. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA. (1997)
High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
J Clin Invest, 100 (5): 1137-43. [PMID:9276730]