CCL2   Click here for help

GtoPdb Ligand ID: 771

Immunopharmacology Ligand
Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
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Immunopharmacology Comments
CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. It is cleaved and activated by MMP12. CCL2 attracts monocytes, memory T cells and dendritic cells to inflammatory sites.
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriasis Disease Ontology: DOID:8893
CCL2 is implicated in the pathogenesis of psoriasis.
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
CCL2 is implicated in the pathogenesis of RA.
Immunopaedia Case Studies Links
A case of cough, wasting and lymphadenopathy