Synonyms: Provigil®
modafinil is an approved drug (FDA (1998))
Compound class:
Synthetic organic
Comment: Modafinil is a eugeroic (wakefulness-promoting) drug with a multi-faceted mechanism of action. In some jurisdictions this drug is classified as a controlled substance due to its possible addiction potential. It has been termed a 'smart' drug, a group of prescription medications, purchased illegally or used off-label, with alleged cognition-enhancing properties [1,4].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Dance A. (2016)
Smart drugs: A dose of intelligence. Nature, 531 (7592): S2-3. [PMID:26934523] |
2. Erman MK, Rosenberg R, Modafinil Shift Work Sleep Disorder Study Group. (2007)
Modafinil for excessive sleepiness associated with chronic shift work sleep disorder: effects on patient functioning and health-related quality of life. Prim Care Companion J Clin Psychiatry, 9 (3): 188-94. [PMID:17632651] |
3. Gerrard P, Malcolm R. (2007)
Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat, 3 (3): 349-64. [PMID:19300566] |
4. Hawkes N. (2015)
Modafinil does enhance cognition, review finds. BMJ, 351: h4573. [PMID:26296947] |
5. Minzenberg MJ, Carter CS. (2008)
Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology, 33 (7): 1477-502. [PMID:17712350] |
6. Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP. (2004)
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. J Med Chem, 47 (24): 5821-4. [PMID:15537337] |
7. Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. (2009)
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther, 329 (2): 738-46. [PMID:19197004] |