IL-17C

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Ligands
IL-17C (Human)

GtoPdb Ligand ID: 5875

Synonyms: cytokine CX2 | interleukin-17C

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-17C is an IL-17 homolog, secreted by epithelial cells in response to bacterial challenge and inflammatory stimuli and that acts in an autocrine manner to control the innate epithelial immune responses necessary for regulating intestinal inflammation and barrier function [1-2].

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

References
1. Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, Hackney J, Kim J, Zhou M, Lai J et al.. (2011) IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol, 12 (12): 1159-66. [PMID:21993848]
2. Reynolds JM, Martinez GJ, Nallaparaju KC, Chang SH, Wang YH, Dong C. (2012) Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C. J Immunol, 189 (9): 4226-30. [PMID:23024280]

References

1. Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, Hackney J, Kim J, Zhou M, Lai J et al.. (2011)
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Nat Immunol, 12 (12): 1159-66. [PMID:21993848]

2. Reynolds JM, Martinez GJ, Nallaparaju KC, Chang SH, Wang YH, Dong C. (2012)
Cutting edge: regulation of intestinal inflammation and barrier function by IL-17C.
J Immunol, 189 (9): 4226-30. [PMID:23024280]