C5a   Click here for help

GtoPdb Ligand ID: 573

Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Ames RS, Nuthulaganti P, Kumar C. (1996)
In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.
FEBS Lett, 395 (2-3): 157-9. [PMID:8898085]
2. Cain SA, Monk PN. (2002)
The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).
J Biol Chem, 277 (9): 7165-9. [PMID:11773063]
3. Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C et al.. (2009)
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.
Am J Respir Crit Care Med, 180 (1): 19-28. [PMID:19324972]
4. Higginbottom A, Cain SA, Woodruff TM, Proctor LM, Madala PK, Tyndall JD, Taylor SM, Fairlie DP, Monk PN. (2005)
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.
J Biol Chem, 280: 17831-17840. [PMID:15661745]
5. Manthey HD, Woodruff TM, Taylor SM, Monk PN. (2009)
Complement component 5a (C5a).
Int J Biochem Cell Biol, 41 (11): 2114-7. [PMID:19464229]
6. Nishiura H, Shibuya Y, Yamamoto T. (1998)
S19 ribosomal protein cross-linked dimer causes monocyte-predominant infiltration by means of molecular mimicry to complement C5a.
Lab Invest, 78 (12): 1615-23. [PMID:9881961]
7. Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP et al.. (2003)
C5L2, a nonsignaling C5A binding protein.
Biochemistry, 42 (31): 9406-15. [PMID:12899627]
8. Paczkowski NJ, Finch AM, Whitmore JB, Short AJ, Wong AK, Monk PN, Cain SA, Fairlie DP, Taylor SM. (1999)
Pharmacological characterization of antagonists of the C5a receptor.
Br J Pharmacol, 128 (7): 1461-6. [PMID:10602324]