C5a 
GtoPdb Ligand ID: 573
|
Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Compound class:
Endogenous peptide in human, mouse or rat
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| Complement component C5a is cleaved from C5 by the protease C5-convertase. C5a exerts pro-inflammatory effects that are mediated via complement activation, formation of the membrane attack complex (MAC), attraction of innate immune cells, and induction of histamine release. Elevated production of C5a is associated with a number of inflammatory diseases [5]. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Sepsis | C5a has been shown to impair phagocytic function and migration of peripheral blood neutrophils isolated from critically ill patients. | 3 | |
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