Synonyms: Adifax® | Fintepla® | Pondimin® | ZX008
fenfluramine is an approved drug (FDA (2020))
Compound class:
Synthetic organic
Comment: The approved drug was called dexfenfluramine, but was withdrawn from use due to adverse cardiac events [1,3].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV. (1997)
Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med, 337 (9): 581-8. [PMID:9271479] |
2. Erickson JD, Schafer MK, Bonner TI, Eiden LE, Weihe E. (1996)
Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc Natl Acad Sci USA, 93 (10): 5166-71. [PMID:8643547] |
3. Mitchell P, Hickie I, Torda T. (1992)
Propofol and ECT. Br J Psychiatry, 161: 861-2. [PMID:1307869] |
4. Pierce JG, Mithal DS. (2020)
Fenfluramine: New Treatment for Seizures in Dravet Syndrome. Pediatr Neurol Briefs, 34: 8. [PMID:32189958] |
5. Vickers SP, Dourish CT, Kennett GA. (2001)
Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology, 41 (2): 200-9. [PMID:11489456] |