YHJ1039   Click here for help

GtoPdb Ligand ID: 13032

Synonyms: compound 26 [PMID: 34324343] | YHJ-1039
Compound class: Synthetic organic
Comment: YHJ1039 is a multikinase inhibitor [1]. Kinase targets include FLT3 (including mutants), FAK, DDR1, TYK2, Fes, Lck, Src, Ros, EphB1, JAK1, JAK3, Ret, Fyn, which are all tyrosine kinases, plus two CMGC group kinases , CDK4 and CK2α1. YHJ1039 has been used as the kinase warhead in cereblon-engaging PROTACs which were shown to act as degraders of the Nek9 kinase [2]
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 123.08
Molecular weight 508.66
XLogP 2.04
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=N3)C(=CS4)C5=CC(=CC=C5)NS(=O)(=O)C
Isomeric SMILES CCN1CCN(CC1)C2=CC=C(NC3=NC4=C(SC=C4C5=CC=CC(NS(C)(=O)=O)=C5)C=N3)C=C2
InChI InChI=1S/C25H28N6O2S2/c1-3-30-11-13-31(14-12-30)21-9-7-19(8-10-21)27-25-26-16-23-24(28-25)22(17-34-23)18-5-4-6-20(15-18)29-35(2,32)33/h4-10,15-17,29H,3,11-14H2,1-2H3,(H,26,27,28)
InChI Key MQMVBXQAIMTOTQ-UHFFFAOYSA-N
References
1. Cho H, Shin I, Yoon H, Jeon E, Lee J, Kim Y, Ryu S, Song C, Kwon NH, Moon Y et al.. (2021)
Identification of Thieno[3,2-d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.
J Med Chem, 64 (16): 11934-11957. [PMID:34324343]
2. Ryu SS, Gadbois GE, Tao AJ, Fram BJ, Jiang J, Boyle B, Donovan KA, Krupnick NM, Berry BC, Bhunia D et al.. (2021)
Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9.
Current Research in Chemical Biology, 1: 100008. DOI: 10.1016/j.crchbi.2021.100008