ontamalimab

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ontamalimab

GtoPdb Ligand ID: 9340

Synonyms: PF-00547659 | PF-547659 | SHP647

Comment: Ontamalimab (PF-00547659) is a fully human, IgG2, investigational monoclonal antibody targeting mucosal addressin cell adhesion molecule 1 (MADCAM1) [1-2]. It is being evaluated for clinical potential in inflammatory bowel diseases. PF-00547659 was granted FDA orphan drug designation for ulcerative colitis in November 2017.

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
MAdCAM-1 binding by PF-00547659 selectively reduces lymphocyte homing to the intestinal tract by blocking interaction with integrin α4β7 [1].

Immunopharmacology Comments

MAdCAM-1 binding by PF-00547659 selectively reduces lymphocyte homing to the intestinal tract by blocking interaction with integrin α4β7 [1].

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Crohn's disease	Disease Ontology: DOID:8778 OMIM: 266600 Orphanet: ORPHA206	Phase 2 clinical candidate for CD (see completed study NCT01298492).
Ulcerative colitis	Disease Ontology: DOID:8577 OMIM: 266600 Orphanet: ORPHA771	Phase 2 clinical candidate for UC (see NCT01771809).	3