ontamalimab   Click here for help

GtoPdb Ligand ID: 9340

Synonyms: PF-00547659 | PF-547659 | SHP647
Immunopharmacology Ligand
Compound class: Antibody
Comment: Ontamalimab (PF-00547659) is a fully human, IgG2, investigational monoclonal antibody targeting mucosal addressin cell adhesion molecule 1 (MADCAM1) [1-2]. It is being evaluated for clinical potential in inflammatory bowel diseases. PF-00547659 was granted FDA orphan drug designation for ulcerative colitis in November 2017.
Bioactivity Comments
PF-00547659 binding exhbits >30-fold difference in target affinity between in vitro SPR (surface plasmon resonance) derived KD and clinically derived KD, thought to be due to conformational restrictions in membrane-bound MAdCAM-1 compared to soluble MAdCAM-1 [4].
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
mucosal addressin cell adhesion molecule 1 {Sp: Human} Peptide Primary target of this compound Hs Antibody Binding 9.7 – 10.8 pKd - 4
⤷ pKd 10.8 (Kd 1.61x10-11 M) [4]
Description: Measured in a SPR assay using recombinant human MAdCAM1.
pKd 9.8 (Kd 1.55x10-10 M) [4]
Description: Measured in a back-scattering interferometry (BSI) assay using membrane-bound MAdCAM1.
pKd 9.7 (Kd 2.07x10-10 M) [4]
Description: Measured in a back-scattering interferometry (BSI) assay using soluble MAdCAM1.