CCL3   Click here for help

GtoPdb Ligand ID: 756

Synonyms: macrophage inflammatory protein-1α | MIP-1α
Immunopharmacology Ligand
Comment: CCL3 is a CC family chemokine more commonly referred to as macrophage inflammatory protein-1α or MIP-1α. It acts in a dimer with CCL4 (MIP-1β) [1].
Species: Human
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Immunopharmacology Comments
CCL3 is a ligand for several chemokine receptors: CCR1, CCR4 and CCR5. Both macrophage inflammatory proteins (MIPs) are chemoattractants for macrophages, monocytes and neutrophils in an acute inflammatory response to bacterial endotoxins [9], and are crucial for immune responses in infection and inflammation [7]. MIP-induced activation of granulocytes (neutrophils, eosinophils and basophils) induces macrophages and fibrobalsts to produce and release pro-inflammatory cytokines (e.g. IL-1, IL-6 and TNF-α). CCL3 is a pyrogen, producing a fever that is resistant to cyclooxygenase inhibitors, and therefore not likely produced by prostaglandin activity.
Immunopaedia Case Studies Links
A case of cough, wasting and lymphadenopathy