Ligand id: 7372

Name: apremilast

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 127.46
Molecular weight 460.13
XLogP 2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
Apremilast is an orally active pan-PDE4 inhibitor [5]. It has regulatory effects on innate immunity, principally by reducing TNF-α production from leukocytes. Apremilast also reduces nitric oxide synthase and IL-23 levels and increases IL-10 levels [3].
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriatic arthritis Disease Ontology: DOID:9008
Approved drug for PsA.