Ligand id: 6464

Name: doxycycline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 6
Rotatable bonds 2
Topological polar surface area 181.62
Molecular weight 444.15
XLogP 0.39
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
Broad-spectrum proteinase inhibitors such as doxycycline might prove of therapeutic value, in particular in the confined microenvironment of the joint space, based on evidence that shows that doxycycline can slow the progression of joint-space narrowing in patients with knee OA [1].