Ligand id: 5702

Name: midostaurin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 77.73
Molecular weight 570.23
XLogP 7.8
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
Midostaurin is a clinically used fms-related tyrosine kinase 3 (FLT3) inhibitor.
Immunopharmacology Disease
Disease X-Refs Comment References
Acute myeloid leukemia Disease Ontology: DOID:9119
OMIM: 601626
Orphanet: ORPHA519
Approved drug for FLT3 mutation +ve AML.
Mastocytosis Disease Ontology: DOID:350
FDA approved drug for aggressive systemic mastocytosis and systemic mastocytosis with associated hematological neoplasm or mast cell leukemia. EMA orphan drug for mastocytosis.