midostaurin

Ligand id: 5702

Name: midostaurin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 77.73
Molecular weight 570.23
XLogP 7.8
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
Midostaurin inhibits proliferation of cells carrying FLT3 translocations or single amino acid changes, and inhibits autophosphorylation of mutant FLT3 receptors [6].
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
fms related receptor tyrosine kinase 3 Hs Inhibitor Inhibition 8.0 pKd - 2
pKd 8.0 (Kd 1.1x10-8 M) [2]
fms related receptor tyrosine kinase 3 Hs Inhibitor Inhibition 6.3 pIC50 - 6
pIC50 6.3 (IC50 5.28x10-7 M) [6]
Ligand mentioned in the following text fields