IL-23A

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Ligands
IL-23A (Human)

GtoPdb Ligand ID: 4989

Synonyms: IL-23p19 | IL23A | interleukin-23 subunit alpha | interleukin-23A

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-23 is a heterodimeric cytokine, sharing a common p40 subunit with IL-12, but having a unique p19 subunit (IL23A).

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
IL-23 is a potent inducer of pro-inflammatory cytokines including IL-6, IL-17, TNFα, IL-22 and GM-CSF, and is a key driver in autoimmune/inflammatory disease [1,3]. Anti-IL-23 antibodies (targeting the p19 subunit) are being developed to ameliorate the effects of IL-23 related diseases or disorders. Such agents would be expected to inhibit IL-23 signaling, IL-23 activation of Th17 cells, IL-23 activation of NK cells, or production of proinflammatory cytokines.

Immunopharmacology Comments

IL-23 is a potent inducer of pro-inflammatory cytokines including IL-6, IL-17, TNFα, IL-22 and GM-CSF, and is a key driver in autoimmune/inflammatory disease [1,3]. Anti-IL-23 antibodies (targeting the p19 subunit) are being developed to ameliorate the effects of IL-23 related diseases or disorders. Such agents would be expected to inhibit IL-23 signaling, IL-23 activation of Th17 cells, IL-23 activation of NK cells, or production of proinflammatory cytokines.