alimemazine   Click here for help

GtoPdb Ligand ID: 7237

Synonyms: Nedeltran® | trimeprazine
Approved drug Immunopharmacology Ligand
alimemazine is an approved drug
Compound class: Synthetic organic
Comment: Alimemazine is a phenothiazine derivative antihistamine.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 298.15
XLogP 4.6
No. Lipinski's rules broken 0
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Canonical SMILES CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C
Isomeric SMILES CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C
InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
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Summary of Clinical Use Click here for help
Used to treat allergic pruritis and motion sickness. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Alimemazine blocks the action of endogenous histamine at the histamine H1 receptor. Anticholinergic activity underlies the drugs additional actions.