alimemazine   Click here for help

GtoPdb Ligand ID: 7237

Synonyms: Nedeltran® | trimeprazine
Approved drug Immunopharmacology Ligand
alimemazine is an approved drug
Compound class: Synthetic organic
Comment: Alimemazine is a phenothiazine derivative antihistamine.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 298.15
XLogP 4.6
No. Lipinski's rules broken 0
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Canonical SMILES CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C
Isomeric SMILES CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C
InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed human molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target. Quantitative data at bovine targets is published in [1] which reports anti-histaminergic and anti-muscarinic effects of alimemazine in bovine brain. Alimemazine antagonises [3H]QNB binding to bovine brain preparations (i.e. muscarinic acetylcholine receptor binding) with a Ki of 38nM [1].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
H1 receptor Bt Antagonist Antagonist 9.1 pKi - 1
pKi 9.1 (Ki 7.2x10-10 M) [1]
Description: Inhibition of [3H]mepyramine binding to bovine brain membrane preparations in vitro.