ulinastatin

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Ligands
ulinastatin (Human)

GtoPdb Ligand ID: 10359

Synonyms: Miraclid® | Ulinase® | Urinastatin®

ulinastatin is an approved drug (Japan, China)

Compound class: Endogenous peptide in human, mouse or rat

Comment: Ulinastatin is considered to be a metabolite of inter-α-trypsin inhibitor (ITI) that is one of the cleavage products from the AMBP precursor protein [3]. Compared to full length ITI, ulinastatin lacks the carboxyterminal RFSN amino acids. Functionally ulinastatin is a protease inhibitor, that plays an important role in physiological and pathological processes, and has notable anti-inflammatory activity [1-2,6]. It can be purified from healthy human urine or produced using recombinant technology.

Species: Human

No information available.

No information available.

Summary of Clinical Use
Highly purified ulinastatin is used clinically for the treatment of acute pancreatitis [2], chronic pancreatitis, Stevens-Johnson syndrome, burns, septic shock [7], and toxic epidermal necrolysis (TEN), principally in Japan, China and India. In the EU, ulinastatin has had orphan drug designation as a treatment for acute pancreatitis since 2014. To review the history of ulinastatin's clinical evaluation click here to link to ClinicalTrials.gov's full list of ulinastatin trials.

Summary of Clinical Use

Highly purified ulinastatin is used clinically for the treatment of acute pancreatitis [2], chronic pancreatitis, Stevens-Johnson syndrome, burns, septic shock [7], and toxic epidermal necrolysis (TEN), principally in Japan, China and India. In the EU, ulinastatin has had orphan drug designation as a treatment for acute pancreatitis since 2014. To review the history of ulinastatin's clinical evaluation click here to link to ClinicalTrials.gov's full list of ulinastatin trials.

Mechanism Of Action and Pharmacodynamic Effects
Ulinastatin inactivates serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, thrombin, and factors IXa, Xa, XIa, and XlIa.

Mechanism Of Action and Pharmacodynamic Effects

Ulinastatin inactivates serine proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, thrombin, and factors IXa, Xa, XIa, and XlIa.