andecaliximab   Click here for help

GtoPdb Ligand ID: 9510

Synonyms: GS-5745 | GS5745
Immunopharmacology Ligand
Compound class: Antibody
Comment: Gilead Sciences designed andecaliximab (GS-5745), a humanized anti-MMP9 monoclonal antibody, for potential to treat solid tumours and inflammatory disorders [1-2]. GS-5745 inhibits MMP-9 activity by a combination of blocking proenzyme (zymogen) conversion to active enzyme, and allosterically inhibiting active MMP-9 catalytic activity [1].
Click here for help
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
MMP9 Primary target of this compound Hs Antibody Binding 9.7 pIC50 - 2
pIC50 9.7 (IC50 2.18x10-10 M) [2]