L-arginine   Click here for help

GtoPdb Ligand ID: 721

Abbreviated name: L-Arg
Compound class: Metabolite
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 127.72
Molecular weight 174.11
XLogP -3.58
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES OC(=O)C(CCCN=C(N)N)N
Isomeric SMILES OC(=O)[C@H](CCCN=C(N)N)N
InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
InChI Key ODKSFYDXXFIFQN-BYPYZUCNSA-N
Natural/Endogenous Targets
Target
GPRC6 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
L-Arginine decarboxylase
Endothelial NOS
Inducible NOS
Neuronal NOS
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
High affinity cationic amino acid transporter 1
Low affinity cationic amino acid transporter 2
Cationic amino acid transporter 3
Mitochondrial ornithine transporter 2 1
Mitochondrial ornithine transporter 1 1
sodium-coupled neutral amino acid transporter 4 2
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPRC6 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 4.4 pEC50 - 3
pEC50 4.4 [3]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields