System A-like transporters | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC38 family of sodium-dependent neutral amino acid transporters
System A-like transporters

System A-like transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1171

Targets of relevance to immunopharmacology are highlighted in blue

SNAT1 (sodium-coupled neutral amino acid transporter 1 / SLC38A1) C Show summary »« Hide summary

SNAT2 (sodium-coupled neutral amino acid transporter 2 / SLC38A2) C Show summary »« Hide summary

SNAT4 (sodium-coupled neutral amino acid transporter 4 / SLC38A4) C Show summary »« Hide summary

Target Id

1171

Nomenclature

sodium-coupled neutral amino acid transporter 4

Systematic nomenclature

SLC38A4

Common abbreviation

SNAT4

Previous and unofficial names

Genes

SLC38A4 (Hs), Slc38a4 (Mm), Slc38a4 (Rn)

Ensembl ID

ENSG00000139209 (Hs), ENSMUSG00000022464 (Mm), ENSRNOG00000006653 (Rn)

UniProtKB AC

Q969I6 (Hs), Q8R1S9 (Mm), Q9EQ25 (Rn)

Bioparadigms SLC Tables

SLC38A4 (Hs)

RESOLUTE

SLC38A4 (Hs)

Substrates

L-histidine > L-arginine, L-alanine, L-asparagine, L-lysine > glycine, L-glutamine, L-serine, L-proline, L-leucine, L-phenylalanine [2]

Substrates

MeAIB

Labelled ligands

[³H]glycine

[¹⁴C]alanine

[³H]alanine

[¹⁴C]glycine

Stoichiometry

1 Na⁺ : 1 neutral amino acid (in) [2]

Comment

Transport of cationic amino acids by SNAT4 was sodium-independent [2].

References

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1. Albers A, Bröer A, Wagner CA, Setiawan I, Lang PA, Kranz EU, Lang F, Bröer S. (2001) Na+ transport by the neural glutamine transporter ATA1. Pflugers Arch, 443 (1): 92-101. [PMID:11692272]

2. Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, Ganapathy V. (2001) Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta, 1510 (1-2): 10-7. [PMID:11342143]

3. Hatanaka T, Huang W, Wang H, Sugawara M, Prasad PD, Leibach FH, Ganapathy V. (2000) Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. Biochim Biophys Acta, 1467 (1): 1-6. [PMID:10930503]

How to cite this family page

Database page citation:

System A-like transporters. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=225.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.