α-CGRP   Click here for help

GtoPdb Ligand ID: 695

Synonyms: αCGRP | rat α-calcitonin gene-related peptide
Compound class: Endogenous peptide in human, mouse or rat
Comment: This peptide is an isoform of calcitonin, encoded by the same gene and produced by alternative splicing.
Species: Mouse, Rat
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
Natural/Endogenous Targets
Target
AM1 receptor
AM2 receptor
AMY1 receptor
AMY2 receptor
AMY3 receptor
CGRP receptor
CT receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
ACKR3 Rn Agonist Agonist 8.5 pEC50 - 6
⤷ pEC50 8.5 (EC50 3x10-9 M) Dose dependant increase of cAMP [6]
CGRP receptor Ligand is endogenous in the given species Rn Agonist Full agonist 8.2 – 8.9 pIC50 - 1,3,5,7
⤷ pIC50 8.2 – 8.9 [1,3,5,7]
CGRP receptor Ligand is endogenous in the given species Mm Agonist Full agonist 8.2 pIC50 - 4
⤷ pIC50 8.2 [4]
AM2 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 7.7 pIC50 - 5
⤷ pIC50 7.7 [5]
AM2 receptor Ligand is endogenous in the given species Mm Agonist Full agonist 7.3 – 7.6 pIC50 - 4
⤷ pIC50 7.3 – 7.6 [4]
AM1 receptor Ligand is endogenous in the given species Rn Agonist Full agonist 6.6 pIC50 - 1
⤷ pIC50 6.6 [1]
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
galcanezumab Peptide Approved drug Rn Antibody Binding 9.9 pKd - 2
⤷ pKd 9.9 (Kd 1.27x10-10 M) [2]