GF109203X   Click here for help

GtoPdb Ligand ID: 5193

Synonyms: bisindolylmaleimide I | Gö6850 | GF 109203X
PDB Ligand
Compound class: Synthetic organic
Comment: GF109203X is a potent, ATP-competitive PKC inhibitor [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 70.13
Molecular weight 412.19
XLogP 3.7
No. Lipinski's rules broken 0
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Canonical SMILES CN(CCCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2)C
Isomeric SMILES CN(CCCn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2)C
InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
Bioactivity Comments
We have mapped the data presented in [3] to the bovine PKC isoforms as the source of the resolved isoforms is unclear in the article.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
protein kinase C beta Bt Inhibitor Inhibition 7.8 pIC50 - 3
pIC50 7.8 (IC50 1.6x10-8 M) [3]
protein kinase C alpha Bt Inhibitor Inhibition 7.7 pIC50 - 3
pIC50 7.7 (IC50 2x10-8 M) [3]
protein kinase C gamma Bt Inhibitor Inhibition 7.7 pIC50 - 3
pIC50 7.7 (IC50 2x10-8 M) [3]
Ligand mentioned in the following text fields