troglitazone   Click here for help

GtoPdb Ligand ID: 2693

Synonyms: CS-045 | Rezulin®
Approved drug
troglitazone is an approved drug (FDA (1997))
Compound class: Synthetic organic
Comment: Troglitazone is an antidiabetic and anti-inflammatory drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 110.16
Molecular weight 441.16
XLogP 3.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCc2c(O1)c(C)c(c(c2C)O)C
Isomeric SMILES O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCc2c(O1)c(C)c(c(c2C)O)C
InChI InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChI Key GXPHKUHSUJUWKP-UHFFFAOYSA-N
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPM3 Hs Channel blocker - - - -
Selectivity at nuclear hormone receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Peroxisome proliferator-activated receptor-γ Primary target of this compound Hs Agonist Full agonist 5.8 pKi - 1
pKi 5.8 (Ki 1.585x10-6 M) [1]
Peroxisome proliferator-activated receptor-γ Primary target of this compound Hs Agonist Full agonist 6.3 pIC50 - 2-3
pIC50 6.3 (IC50 5.012x10-7 M) [2-3]