valemetostat   Click here for help

GtoPdb Ligand ID: 12282

Synonyms: (R)-OR-S2 [2] | DS-3201 | DS3201 | Ezharmia®
Approved drug
valemetostat is an approved drug (Japan (2022))
Compound class: Synthetic organic
Comment: Valemetostat (DS-3201) is an orally bioavailable, S-adenosylmethionine (SAM)-competitive inhibitor of the histone methyltransferases enhancer of zeste homologue 1 and 2 (EZH1/EZH2) [2] that are responsible for tri-methylation of lysine 27 on histone H3 (H3K27me3) by the polycomb repressive complex 2 (PRC2). H3K27me3 is an epigenetic modification that represses transcription of tumour suppressor and cell differentiation genes). Valemetostat was developed to target cancers with ongogenic defects that are driven by excessive activity of EZH1 and EZH2 [4-5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 83.66
Molecular weight 487.22
XLogP 5.25
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN(C1CCC(CC1)[C@@]1(C)Oc2c(O1)c(C)c(cc2Cl)C(=O)NCc1c(C)cc([nH]c1=O)C)C
Isomeric SMILES Cc1cc(c(c(=O)[nH]1)CNC(=O)c1cc(c2c(c1C)O[C@@](O2)(C)C1CCC(CC1)N(C)C)Cl)C
InChI InChI=1S/C26H34ClN3O4/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32)/t17?,18?,26-/m1/s1
InChI Key SSDRNUPMYCFXGM-ZZHSESOFSA-N
Bioactivity Comments
Dual EZH1/2 inhibitors appear to more potently inhibit H3K27me3 in vitro than EZH2 selective inhibitors. the R-enantiomer of valemetostat is more potent that a racemic mixture of stereoisomers [2]. In a screening panel including EZH1/2 and other methyltransferases valemetostat demonstrated selectivity for EZH1/2.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
enhancer of zeste 2 polycomb repressive complex 2 subunit Hs Inhibitor Inhibition 8.3 pIC50 - 2
⤷ pIC50 8.3 (IC50 5.1x10-9 M) [2]
enhancer of zeste 1 polycomb repressive complex 2 subunit Hs Inhibitor Inhibition 7.8 pIC50 - 2
⤷ pIC50 7.8 (IC50 1.6x10-8 M) [2]