Synonyms: TTK-21
Compound class:
Synthetic organic
Comment: TTK21 is a small molecule activator of CREB-binding protein (CREBBP) and p300 (EP300) histone acetyltransferases [2]. It reaches the brain when administered intraperitonealy as a glucose-based carbon nanosphere conjugate. TTK21 induces axon regeneration in in vivo models of spinal injury [3] and neurodegeneration [1-2,4].
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Bioactivity Comments |
TTK21 increases the histone acetyltransferase (HAT) activities of CREB-binding protein and p300 in a concentration-dependent manner in vitro (maximal activation at 250-275 μM) [2] |
Selectivity at other protein targets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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