GnRH I

Ligand id: 1162

Name: GnRH I

Species: Human, Mouse, Rat

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: gnrh

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Natural/Endogenous Targets
Target
GnRH1 receptor
GnRH2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GnRH1 receptor Hs Agonist Full agonist 7.7 – 8.5 pKd - 6
pKd 7.7 – 8.5 (Kd 2.2x10-8 – 2.9x10-9 M) [6]
GnRH1 receptor Hs Agonist Full agonist 7.3 – 8.4 pKi - 1,6,9
pKi 7.9 – 8.4 (Ki 1.3x10-8 – 4x10-9 M) [6]
pKi 7.3 – 8.4 [1,9]
GnRH1 receptor Rn Agonist Full agonist 6.8 pKi - 1
pKi 6.8 [1]
GnRH1 receptor Hs Agonist Full agonist 10.0 pEC50 - 7
pEC50 10.0 (EC50 1x10-10 M) [7]
GnRH1 receptor Mm Agonist Full agonist 7.8 – 7.9 pEC50 - 7
pEC50 7.8 – 7.9 (EC50 1.7x10-8 – 1.2x10-8 M) [7]
GnRH1 receptor Hs Agonist Full agonist 8.6 pIC50 - 3
pIC50 8.6 [3]
GnRH1 receptor Mm Agonist Full agonist 8.3 pIC50 - 8
pIC50 8.3 [8]
GnRH1 receptor Rn Agonist Full agonist 7.7 pIC50 - 2
pIC50 7.7 [2]
GnRH2 receptor Monkey Agonist Full agonist 7.4 pIC50 - 4-5
pIC50 7.4 (IC50 4.26x10-8 M) [4-5]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields