Ligand id: 1162

Name: GnRH I

Species: Human, Mouse, Rat

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Structure and Physico-chemical Properties

2D Structure
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1. Beckers T, Bernd M, Kutscher B, Kühne R, Hoffmann S, Reissmann T. (2001)
Structure-function studies of linear and cyclized peptide antagonists of the GnRH receptor.
Biochem. Biophys. Res. Commun., 289 (3): 653-63. [PMID:11726197]
2. Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. (1994)
Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein.
Endocrinology, 135 (1): 315-20. [PMID:8013367]
3. Lu ZL, Coetsee M, White CD, Millar RP. (2007)
Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.
J. Biol. Chem., 282 (24): 17921-9. [PMID:17452338]
4. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R et al.. (2001)
A novel mammalian receptor for the evolutionarily conserved type II GnRH.
Proc. Natl. Acad. Sci. U.S.A., 98 (17): 9636-41. [PMID:11493674]
5. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. (2004)
Gonadotropin-releasing hormone receptors.
Endocr. Rev., 25 (2): 235-75. [PMID:15082521]
6. Nederpelt I, Georgi V, Schiele F, Nowak-Reppel K, Fernández-Montalván AE, IJzerman AP, Heitman LH. (2016)
Characterization of 12 GnRH peptide agonists - a kinetic perspective.
Br. J. Pharmacol., 173 (1): 128-41. [PMID:26398856]
7. Nederpelt I, Vergroesen RD, IJzerman AP, Heitman LH. (2016)
Persistent GnRH receptor activation in pituitary αT3-1 cells analyzed with a label-free technology.
Biosens Bioelectron, 79: 721-7. [PMID:26774084]
8. Reinhart J, Mertz LM, Catt KJ. (1992)
Molecular cloning and expression of cDNA encoding the murine gonadotropin-releasing hormone receptor.
J. Biol. Chem., 267 (30): 21281-4. [PMID:1328228]
9. Struthers RS, Xie Q, Sullivan SK, Reinhart GJ, Kohout TA, Zhu YF, Chen C, Liu XJ, Ling N, Yang W et al.. (2007)
Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902.
Endocrinology, 148 (2): 857-67. [PMID:17095587]