GnRH I   Click here for help

GtoPdb Ligand ID: 1162

Synonyms: GnRH | gonadoliberin | gonadotropin releasing hormone | LH-RH (LHRH)
Species: Human, Mouse, Rat
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: gnrh

2D Structure
Click here for help
Click here for structure editor
Click here for help
Canonical SMILES OCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NCC(=O)N)CC(C)C)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)O)NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C1CCC(=O)N1)Cc1[nH]cnc1
Isomeric SMILES OCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NCC(=O)N)CC(C)C)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)O)NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C1CCC(=O)N1)Cc1[nH]cnc1
InChI InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)
1. Beckers T, Bernd M, Kutscher B, Kühne R, Hoffmann S, Reissmann T. (2001)
Structure-function studies of linear and cyclized peptide antagonists of the GnRH receptor.
Biochem Biophys Res Commun, 289 (3): 653-63. [PMID:11726197]
2. Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. (1994)
Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein.
Endocrinology, 135 (1): 315-20. [PMID:8013367]
3. Lu ZL, Coetsee M, White CD, Millar RP. (2007)
Structural determinants for ligand-receptor conformational selection in a peptide G protein-coupled receptor.
J Biol Chem, 282 (24): 17921-9. [PMID:17452338]
4. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R et al.. (2001)
A novel mammalian receptor for the evolutionarily conserved type II GnRH.
Proc Natl Acad Sci USA, 98 (17): 9636-41. [PMID:11493674]
5. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, Maudsley SR. (2004)
Gonadotropin-releasing hormone receptors.
Endocr Rev, 25 (2): 235-75. [PMID:15082521]
6. Nederpelt I, Georgi V, Schiele F, Nowak-Reppel K, Fernández-Montalván AE, IJzerman AP, Heitman LH. (2016)
Characterization of 12 GnRH peptide agonists - a kinetic perspective.
Br J Pharmacol, 173 (1): 128-41. [PMID:26398856]
7. Nederpelt I, Vergroesen RD, IJzerman AP, Heitman LH. (2016)
Persistent GnRH receptor activation in pituitary αT3-1 cells analyzed with a label-free technology.
Biosens Bioelectron, 79: 721-7. [PMID:26774084]
8. Reinhart J, Mertz LM, Catt KJ. (1992)
Molecular cloning and expression of cDNA encoding the murine gonadotropin-releasing hormone receptor.
J Biol Chem, 267 (30): 21281-4. [PMID:1328228]
9. Struthers RS, Xie Q, Sullivan SK, Reinhart GJ, Kohout TA, Zhu YF, Chen C, Liu XJ, Ling N, Yang W et al.. (2007)
Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902.
Endocrinology, 148 (2): 857-67. [PMID:17095587]