loncastuximab tesirine   Click here for help

GtoPdb Ligand ID: 11521

Synonyms: ADCT-402 | ADCT402 | loncastuximab tesirine-lpyl | RB4v1.2-SG-3249 | Zynlonta®
Approved drug
loncastuximab tesirine is an approved drug (FDA (2021), EMA (2022))
Compound class: Antibody
Comment: Loncastuximab tesirine (ADCT-402) is an antibody-drug conjugate that delivers the toxic payload teserine (pyrrolobenzodiazepine dimer SG3249, which acts as a DNA alkylating and cross-linking agent [3]) to CD19-expressing B cells [4].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD19 Hs Antibody Binding - - - 4
⤷ [4]