ravulizumab   Click here for help

GtoPdb Ligand ID: 10168

Synonyms: ALXN-1210 | ALXN1210 | ravulizumab-cwvz | Ultomiris®
Approved drug Immunopharmacology Ligand
ravulizumab is an approved drug (FDA (2018), EMA (2019))
Compound class: Antibody
Comment: Ravulizumab (ALXN1210; Ultomiris) is a humanized monoclonal antibody that binds to human complement component C5. It was developed by Alexion as a next-generation anti-C5 therapy for paroxysmal nocturnal hemoglobinuria (PNH) that was engineered from their already approved PNH agent eculizumab (Soliris), but was designed to have an inherently longer circulating half-life so as to extend dosing intervals to once/month [3].
Peptide sequence and secondary structural information for this antibody are available from its IMGT/mAb-DB record.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C5 Primary target of this compound Hs Antibody Binding 7.7 – 9.3 pKd - 3
pKd 9.3 (Kd 4.9x10-10 M) [3]
Description: At pH7.4 in a SPR assay.
pKd 7.7 (Kd 2.2x10-8 M) [3]
Description: At pH6.0 in a SPR assay.