CXCL10   Click here for help

GtoPdb Ligand ID: 835

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL10 is a C-X-C motif chemokine preferentially expressed by Th1 lymphocytes. It exerts its biological effects via interaction with the CXCR3 GPCR.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Deshpande S, Huang H, Srinivasan M, Cardarelli JM, Wang C, Passmore DB, Rangan V, Lane TE, Keirstead HS, Liu MT. (2012)
IP-10 antibodies and their uses.
Patent number: US8258266 B2. Assignee: Medarex, Inc.. Priority date: 10/12/2003. Publication date: 04/09/2012.
2. Heise CE, Pahuja A, Hudson SC, Mistry MS, Putnam AL, Gross MM, Gottlieb PA, Wade WS, Kiankarimi M, Schwarz D et al.. (2005)
Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
J Pharmacol Exp Ther, 313 (3): 1263-71. [PMID:15761110]
3. Lee EY, Lee ZH, Song YW. (2009)
CXCL10 and autoimmune diseases.
Autoimmun Rev, 8 (5): 379-83. [PMID:19105984]
4. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]
5. Zhang H, Maqsudi S, Rainczuk A, Duffield N, Lawrence J, Keane FM, Justa-Schuch D, Geiss-Friedlander R, Gorrell MD, Stephens AN. (2015)
Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.
FEBS J, 282 (19): 3737-57. [PMID:26175140]