atezolizumab   Click here for help

GtoPdb Ligand ID: 7990

Synonyms: MPDL3280A | Tecentriq®
Approved drug Immunopharmacology Ligand
atezolizumab is an approved drug (FDA (2016), EMA (2017))
Compound class: Antibody
Comment: Atezolizumab (MPDL3280A) is a monoclonal antibody directed against programmed death-1 ligand-1 (PD-L1, aka CD274), an important immunopharmacological drug discovery target in immuno-oncology.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence analysis using the light chain variable region of atezolizumab provides a 100% match to sequence 21 from patent US8217149. An X-ray crystal structure of the PD-L1/atezolizumab complex has been submitted to the RCSB PDB (accession 5X8L) [3].
Immunopharmacology Comments
Atezolizumab is an immuno-oncology agent. It is an immune checkpoint inhibitor, a mechanism of action now widely accepted as efficacious for cancer immunotherapy [4,7].