Ligand id: 6892

Name: belatacept

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Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes (FDA (2011), EMA (2011))
International Nonproprietary Names
INN number INN
8627 belatacept
BMS-224818 | LEA29Y | Nulojix®
A recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). CTLA-4 is essential for T-cell co-activation.
Belatecept differs from abatacept by only 2 amino acids.
Database Links
Specialist databases
IMGT/mAb-DB 247
Other databases
ChEMBL Ligand CHEMBL1742990 (Hs)
DrugBank Ligand DB06681
GtoPdb PubChem SID 178103474
PubChem SID 135283321
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Wikipedia Belatacept