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TL1A   Click here for help

GtoPdb Ligand ID: 5071

Synonyms: Tumor necrosis factor ligand superfamily member 15, membrane form
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TL1A occurs as both membrane‐bound and soluble forms. It principally functions as a negative modulator of epithelial cell proliferation. Inhibiting the TL1A/death receptor 3 (TNFRSF25) pathway has been proposed as mechanism to treat inflammatory bowel disease [1]. In addition, TL1A has been associated with tumourigenesis and progression of some gastrointestinal malignancies [3,5,7], making it a target of interest for the development of novel anti-cancer drugs.
Species: Human
No information available.
Summary of Clinical Use Click here for help
TL1A is being evaluated as a therapeutic target as a novel mechanism for ulcerative colitis treatment. PF-06480605 is a first-in-class TL1A blocking monoclonal antibody that inhibits pro-inflammatory cytokine production by T cell subsets [1].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04090411 A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adult Participants With Moderate to Severe Ulcerative Colitis Phase 2 Interventional Pfizer 1