IL-23A

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Ligands
IL-23A (Human)

GtoPdb Ligand ID: 4989

Synonyms: IL-23p19 | IL23A | interleukin-23 subunit alpha | interleukin-23A

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-23 is a heterodimeric cytokine, sharing a common p40 subunit with IL-12, but having a unique p19 subunit (IL23A).

Species: Human

References
1. Ahern PP, Izcue A, Maloy KJ, Powrie F. (2008) The interleukin-23 axis in intestinal inflammation. Immunol Rev, 226: 147-59. [PMID:19161422]
2. Beidler CB, Bright SW, Girard DS, Kikly KK. (2015) Antibodies that bind to IL-23. Patent number: US9023358B2. Assignee: Eli Lilly and Co Ltd (GB). Priority date: 08/03/2013. Publication date: 05/05/2015.
3. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T et al.. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature, 421 (6924): 744-8. [PMID:12610626]
4. Presta LG, Beyer BM, Ingram RN, Orth P, Liu Y-H. (2011) Engineered Anti-IL-23p19 Antibodies. Patent number: US20110142853. Assignee: Schering Corporation. Priority date: 23/02/2007. Publication date: 16/06/2011.
5. Singh S, Kroe-Barrett RR, Canada KA, Zhu X, Sepulveda E, Wu H, He Y, Raymond EL, Ahlberg J, Frego LE et al.. (2015) Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody. MAbs, 7 (4): 778-91. [PMID:25905918]
6. Towne JE, Cheng JD, O'neill JC, Zhang Y, Sun Y, Cerne H, Piper DE, Ketcherm RR. (2011) Human il-23 antigen binding proteins. Patent number: WO2011056600. Assignee: Amgen Inc.. Priority date: 26/10/2009. Publication date: 12/05/2011.
7. Zhou L, Wang Y, Wan Q, Wu F, Barbon J, Dunstan R, Gauld S, Konrad M, Leys L, McCarthy R et al.. (2021) A non-clinical comparative study of IL-23 antibodies in psoriasis. MAbs, 13 (1): 1964420. [PMID:34460338]

References

1. Ahern PP, Izcue A, Maloy KJ, Powrie F. (2008)
The interleukin-23 axis in intestinal inflammation.
Immunol Rev, 226: 147-59. [PMID:19161422]

2. Beidler CB, Bright SW, Girard DS, Kikly KK. (2015)
Antibodies that bind to IL-23.
Patent number: US9023358B2. Assignee: Eli Lilly and Co Ltd (GB). Priority date: 08/03/2013. Publication date: 05/05/2015.

3. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T et al.. (2003)
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.
Nature, 421 (6924): 744-8. [PMID:12610626]

4. Presta LG, Beyer BM, Ingram RN, Orth P, Liu Y-H. (2011)
Engineered Anti-IL-23p19 Antibodies.
Patent number: US20110142853. Assignee: Schering Corporation. Priority date: 23/02/2007. Publication date: 16/06/2011.

5. Singh S, Kroe-Barrett RR, Canada KA, Zhu X, Sepulveda E, Wu H, He Y, Raymond EL, Ahlberg J, Frego LE et al.. (2015)
Selective targeting of the IL23 pathway: Generation and characterization of a novel high-affinity humanized anti-IL23A antibody.
MAbs, 7 (4): 778-91. [PMID:25905918]

6. Towne JE, Cheng JD, O'neill JC, Zhang Y, Sun Y, Cerne H, Piper DE, Ketcherm RR. (2011)
Human il-23 antigen binding proteins.
Patent number: WO2011056600. Assignee: Amgen Inc.. Priority date: 26/10/2009. Publication date: 12/05/2011.

7. Zhou L, Wang Y, Wan Q, Wu F, Barbon J, Dunstan R, Gauld S, Konrad M, Leys L, McCarthy R et al.. (2021)
A non-clinical comparative study of IL-23 antibodies in psoriasis.
MAbs, 13 (1): 1964420. [PMID:34460338]