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fenfluramine   Click here for help

GtoPdb Ligand ID: 4613

Synonyms: Adifax® | Fintepla® | Pondimin® | ZX008
Approved drug
fenfluramine is an approved drug (FDA (2020))
Compound class: Synthetic organic
Comment: The approved drug was called dexfenfluramine. It withdrawn from use as a weight-loss aid due to adverse cardiac events [1,3]. Fenfluramine has subsequently been re-introduced as an anti-seizure medication for rare forms of pediatric intractable epilepsy.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 12.03
Molecular weight 231.12
XLogP 3.5
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCNC(Cc1cccc(c1)C(F)(F)F)C
Isomeric SMILES CCNC(Cc1cccc(c1)C(F)(F)F)C
InChI InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
InChI Key DBGIVFWFUFKIQN-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2020)
IUPAC Name Click here for help
ethyl({1-[3-(trifluoromethyl)phenyl]propan-2-yl})amine
International Nonproprietary Names Click here for help
INN number INN
5818 dexfenfluramine
1596 fenfluramine
Synonyms Click here for help
Adifax® | Fintepla® | Pondimin® | ZX008
Database Links Click here for help
CAS Registry No. 458-24-2 (source: Scifinder)
ChEBI CHEBI:5000
ChEMBL Ligand CHEMBL87493
DrugBank Ligand DB01191
DrugCentral Ligand 1150
GtoPdb PubChem SID 178101333
PubChem CID 3337
Search Google for chemical match using the InChIKey DBGIVFWFUFKIQN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DBGIVFWFUFKIQN
Search PubMed clinical trials fenfluramine
Search PubMed titles fenfluramine
Search PubMed titles/abstracts fenfluramine
UniChem Compound Search for chemical match using the InChIKey DBGIVFWFUFKIQN-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey DBGIVFWFUFKIQN-UHFFFAOYSA-N
Wikipedia Fenfluramine