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XCL2   Click here for help

GtoPdb Ligand ID: 4370

Synonyms: C motif cytokine 2 | lymphotactin β
Immunopharmacology Ligand
Comment: XCL2 is a C subfamily chemokine, closely related to XCL1. It alternates between monomeric and dimeric states under physiological NaCl and temperature conditions. The monomeric form activates its G protein-coupled receptor XCR1, and the dimeric form is important for glycosaminoglycan (GAG) binding [1].
Species: Human
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Natural/Endogenous Targets
Target
XCR1
Selectivity at GPCRs
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Target
Sp.
Type
Action
Value
Parameter
Reference
XCR1 Ligand is endogenous in the given species Hs Agonist Agonist ~7.3 pEC50 - 1
pEC50 ~7.3 (EC50 ~5x10-8 M) [1]
Description: Measuring Ca2+ flux