XCL2   Click here for help

GtoPdb Ligand ID: 4370

Synonyms: C motif cytokine 2 | lymphotactin β
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: XCL2 is a C subfamily chemokine, closely related to XCL1. It alternates between monomeric and dimeric states under physiological NaCl and temperature conditions. The monomeric form activates its G protein-coupled receptor XCR1, and the dimeric form is important for glycosaminoglycan (GAG) binding [1].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
Physiological roles specific for each of the highly related chemokines XCL1 and XCL2 are likely due to different expression patterns [1]. They both act through the same G protein-coupled receptor, XCR1 [3]. In some cancers (epithelial ovarian and hepatocellular carcinoma) elevated XCL2 expression correlates with cancer progression [2].