Synonyms: IFB-088 | IFB088 | Sephin-1 | Sephin1
Compound class:
Synthetic organic
Comment: Icerguastat (IFB-088, Sephin1) selectively inhibits the regulatory subunit PPP1R15A within the PPP1R15A/PP1c phosphatase complex [2]. Inhibiting PPP1R15A results in reduced dephosphorylation of the translation initiation factor eIF2α, which rescues cells from proteostasis collapse. Structurally icerguastat is a guanabenz derivative but it has no α2-adrenerceptor agonist activity. Icerguastat is designed to maintain an active integrated stress response as a cytoprotective mechanism to combat the toxic effects of cellular stress [1].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-[(E)-(2-chlorophenyl)methylideneamino]guanidine |
International Nonproprietary Names | |
INN number | INN |
11189 | icerguastat |
Synonyms |
IFB-088 | IFB088 | Sephin-1 | Sephin1 |
Database Links | |
CAS Registry No. | 951441-04-6 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL2365743 |
DrugBank Ligand | DB16932 |
GtoPdb PubChem SID | 491300045 |
PubChem CID | 9561611 |
Search Google for chemical match using the InChIKey | PDWJALXSRRSUHR-LFYBBSHMSA-N |
Search Google for chemicals with the same backbone | PDWJALXSRRSUHR |
Search PubMed clinical trials | icerguastat |
Search PubMed titles | icerguastat |
Search PubMed titles/abstracts | icerguastat |
UniChem Compound Search for chemical match using the InChIKey | PDWJALXSRRSUHR-LFYBBSHMSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | PDWJALXSRRSUHR-LFYBBSHMSA-N |