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ChEMBL ligand: CHEMBL209148 (BMS-509744) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of Cdk2 | B | 4.54 | pIC50 | 29000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 4.44 | pIC50 | 36000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of Insulin receptor | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of ERK1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of Akt1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
ChEMBL | Inhibition of Btk | B | 5.39 | pIC50 | 4100 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibition of Fyn | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
ChEMBL | Inhibition of ITK | B | 7.8 | pKi | 16 | nM | Ki | Chem Biol (2005) 12: 621-637 [PMID:15975507] |
GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-12 [PMID:16682193] |
ChEMBL | Inhibition of Itk | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
ChEMBL | Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISA | B | 7.99 | pIC50 | 10.3 | nM | IC50 | J Med Chem (2022) 65: 2694-2709 [PMID:35099969] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of Syk | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680] | ||||||||
ChEMBL | Inhibition of Tec | B | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] | ||||||||
ChEMBL | Inhibition of Txk | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]