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ChEMBL ligand: CHEMBL1090089 (Pamapimod, R1503, R-1503, Ro-4402257, RO 4402257) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
ChEMBL | Binding affinity to CSNK1epsilon | B | 6.59 | pKd | 260 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of CSNK1epsilon | B | 6.59 | pKd | 260 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60] | ||||||||
ChEMBL | Inhibition of ADCK3 | B | 6 | pKd | >1000 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
GtoPdb | In a biochemical assay. | - | 6.72 | pKd | 190 | nM | Kd | J Med Chem (2011) 54: 2255-65 [PMID:21375264] |
ChEMBL | Binding affinity to JNK1 | B | 6.72 | pKd | 190 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of JNK1 | B | 6.72 | pKd | 190 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
ChEMBL | Inhibition of JNK1 (unknown origin) | B | 5.27 | pIC50 | 5420 | nM | IC50 | Bioorg. Med. Chem. Lett. (2016) 26: 424-428 [PMID:26704265] |
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
ChEMBL | Binding affinity to JNK2 | B | 7.8 | pKd | 16 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of JNK2 | B | 7.8 | pKd | 16 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
GtoPdb | In a biochemical assay. | - | 7.8 | pKd | 16 | nM | Kd | J Med Chem (2011) 54: 2255-65 [PMID:21375264] |
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
GtoPdb | In a biochemical assay. | - | 7.72 | pKd | 19 | nM | Kd | J Med Chem (2011) 54: 2255-65 [PMID:21375264] |
ChEMBL | Binding affinity to JNK3 | B | 7.72 | pKd | 19 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of JNK3 | B | 7.72 | pKd | 19 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
ChEMBL | Inhibition of DDR1 | B | 6 | pKd | >1000 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
ChEMBL | Binding affinity to p38alpha | B | 8.89 | pKd | 1.3 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of p38alpha | B | 8.89 | pKd | 1.3 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
GtoPdb | In a biochemical assay. | - | 8.89 | pKd | 1.3 | nM | Kd | J Med Chem (2011) 54: 2255-65 [PMID:21375264] |
ChEMBL | Inhibition of human recombinant p38alpha by liquid scintillation counting | B | 7.85 | pIC50 | 14 | nM | IC50 | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of human recombinant p38alpha assessed as incorporation of 33P from gamma-[33P]ATP into myelin basic protein after 30 mins by scintillation counting | B | 7.85 | pIC50 | 14 | nM | IC50 | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
GtoPdb | In a biochemical assay. | - | 6.92 | pKd | 120 | nM | Kd | J Med Chem (2011) 54: 2255-65 [PMID:21375264] |
ChEMBL | Binding affinity to p38beta | B | 6.92 | pKd | 120 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of P38beta | B | 6.92 | pKd | 120 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
ChEMBL | Inhibition of RSK2 | B | 6.52 | pKd | 300 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
ChEMBL | Inhibition of RSK4 | B | 6.82 | pKd | 150 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7] | ||||||||
ChEMBL | Inhibition of STK36 | B | 6 | pKd | >1000 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976] | ||||||||
ChEMBL | Inhibition of GAK | B | 6 | pKd | >1000 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8] | ||||||||
ChEMBL | Binding affinity to NLK | B | 6.77 | pKd | 170 | nM | Kd | J. Med. Chem. (2010) 53: 2345-2353 [PMID:19950901] |
ChEMBL | Inhibition of NLK | B | 6.77 | pKd | 170 | nM | Kd | J. Med. Chem. (2011) 54: 2255-2265 [PMID:21375264] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]