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ChEMBL ligand: CHEMBL188381 (GW806742X) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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mixed lineage kinase domain like pseudokinase/Mixed lineage kinase domain-like protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938217] [GtoPdb: 2106] [UniProtKB: Q8NB16] | ||||||||
GtoPdb | Surface plasmon resonance (SPR) assay. | - | 5.03 | pKd | 9300 | nM | Kd | Proc Natl Acad Sci USA (2014) 111: 15072-7 [PMID:25288762] |
ChEMBL | Binding affinity to MLKL (unknown origin) | B | 5.03 | pKd | 9300 | nM | Kd | J Med Chem (2020) 63: 1490-1510 [PMID:31622096] |
GtoPdb | Inhibition of TSQ-induced necroptosis in cellular assays. | - | 7 | pIC50 | 100 | nM | IC50 | Proc Natl Acad Sci USA (2014) 111: 15072-7 [PMID:25288762] |
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
ChEMBL | Further kinetic evaluation of compounds supplied by Sanofi against AuroraA within a BIAcore3000 instrument | B | 4.9 | pKd | 12461.05 | nM | Kd | K4DD drug target binding kinetics data |
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
ChEMBL | Inhibitory concentration against human VEGFR2 kinase | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3519-3523 [PMID:15990302] |
GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3519-23 [PMID:15990302] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]