compound 43 [PMID: 26751273] [Ligand Id: 9492] activity data from GtoPdb

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  • S1P1 receptor in Human [GtoPdb: 275] [UniProtKB: P21453]
Created with Highcharts 10.3.3ValuesChart context menuS1P1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • S1P2 receptor in Human [GtoPdb: 276] [UniProtKB: O95136]
Created with Highcharts 10.3.3ValuesChart context menuS1P2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • S1P3 receptor in Human [GtoPdb: 277] [UniProtKB: Q99500]
Created with Highcharts 10.3.3ValuesChart context menuS1P3 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • S1P4 receptor in Human [GtoPdb: 278] [UniProtKB: O95977]
Created with Highcharts 10.3.3ValuesChart context menuS1P4 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human012345Highcharts.com
  • S1P5 receptor in Human [GtoPdb: 279] [UniProtKB: Q9H228]
Created with Highcharts 10.3.3ValuesChart context menuS1P5 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor in Human [GtoPdb: 275] [UniProtKB: P21453]
GtoPdb In β-arrestin and receptor internalisation assays. - 8.8 pEC50 - - - J Med Chem (2016) 59: 1003-20 [PMID:26751273]
S1P2 receptor in Human [GtoPdb: 276] [UniProtKB: O95136]
GtoPdb In a S1P2R yeast reporter assay. - 4.5 pEC50 <31628 nM EC50 J Med Chem (2016) 59: 1003-20 [PMID:26751273]
S1P3 receptor in Human [GtoPdb: 277] [UniProtKB: Q99500]
GtoPdb In a GTPγS assay. - 5.1 pEC50 7943 nM EC50 J Med Chem (2016) 59: 1003-20 [PMID:26751273]
S1P4 receptor in Human [GtoPdb: 278] [UniProtKB: O95977]
GtoPdb In an aequorin calcium accumulation assay. - 4.4 pEC50 <39810 nM EC50 J Med Chem (2016) 59: 1003-20 [PMID:26751273]
S1P5 receptor in Human [GtoPdb: 279] [UniProtKB: Q9H228]
GtoPdb In an aequorin calcium accumulation assay. - 7.78 pEC50 16.6 nM EC50 J Med Chem (2016) 59: 1003-20 [PMID:26751273]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.