ChEMBL ligand: CHEMBL13647 (BMY-7378)
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130] α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant Alpha-1A adrenergic receptor	B	6.42	pKd	380.19	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Binding affinity at human cloned Alpha-1A adrenergic receptor in chinese hamster ovary cells by [3H]-prazosin displacement.	B	6.36	pKi	436.52	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Displacement of [3H]prazosin from recombinant human alpha1a adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method	B	6.41	pKi	389.05	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]Prazosin from human recombinant alpha 1A adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay	B	6.42	pKi	380.19	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Displacement of [3H]prazosin from human alpha1A adrenergic receptor expressed in CHO cells	B	6.42	pKi	380.19	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Displacement [3H]prazosin of human recombinant alpha1A adrenergic receptor expressed in CHO cells by rapid filtration technique	B	6.42	pKi	380.19	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1A adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting	B	6.42	pKi	380.19	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins	B	6.42	pKi	380.19	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1A adrenergic receptor	B	6.42	pKi	380.19	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Displacement of [3H]prazosin from human cloned alpha1A adrenoceptor expressed in CHO cells	B	6.42	pKi	380.19	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL	Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1A adrenergic receptor (n >= 2)	B	6.53	pKi	294	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	Binding affinity for human Alpha-1A adrenergic receptor	B	6.54	pKi	290	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	In vitro binding affinity at human Alpha-1A adrenergic receptor.	B	6.6	pKi	251	nM	Ki	J Med Chem (2003) 46: 2877-2894 [PMID:12825930]
ChEMBL	Binding constant measured against Alpha-1A adrenergic receptor in human prostate; +:inactive	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 657-664 [PMID:15664832]
ChEMBL	Binding affinity for human Alpha-1A adrenergic receptor	B	6.89	pKi	130	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb	-	-	7	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]; Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL	Binding affinity towards bovine Alpha-1A adrenergic receptor	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	In vitro functional activity at Alpha-1A adrenergic receptor in rat vas deferens	B	5.98	pKd	1047.13	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.	F	6.94	pKd	114.82	nM	Kd	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	F	7.01	pKd	97.72	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1A adrenergic receptor	B	6.21	pKi	620	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]prazosin in epididymal rat vas deferens.	B	6.31	pKi	494.7	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Binding affinity towards rat Alpha-1A adrenergic receptor	B	6.95	pKi	112	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
GtoPdb	-	-	7	pKi	-	-	-	Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1B adrenoceptor expressed in CHO cells	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL	Displacement [3H]prazosin of human recombinant Alpha-1B adrenergic receptor expressed in CHO cells by rapid filtration technique	B	6.15	pKi	707.95	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]prazosin from recombinant human alpha1b adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method	B	6.15	pKi	707.95	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Displacement of [3H]Prazosin from human recombinant alpha 1B adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay	B	6.15	pKi	707.95	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells	B	6.15	pKi	707.95	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptor	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting	B	6.15	pKi	707.95	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	In vitro binding affinity at human Alpha-1B adrenergic receptor.	B	6.2	pKi	631	nM	Ki	J Med Chem (2003) 46: 2877-2894 [PMID:12825930]
ChEMBL	Binding affinity for human Alpha-1B adrenergic receptor	B	6.72	pKi	191	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1B adrenergic receptor (n >= 2)	B	6.72	pKi	191	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen	B	6.77	pKi	168.2	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Binding affinity towards human Alpha-1B adrenergic receptor	B	7.03	pKi	94.3	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptor	B	7.16	pKi	69.18	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Binding affinity at human cloned Alpha-1B adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.	B	7.19	pKi	64.57	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
GtoPdb	-	-	7.5	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]; Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL	In vitro functional activity at Alpha-1B adrenergic receptor in rat spleen	F	7.37	pKd	42.66	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor	F	7.48	pKd	33.11	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Antagonism of phenylephrine stimulated contraction of the rat isolated spleen.	F	7.55	pKd	28.18	nM	Kd	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1B adrenergic receptor	B	6.48	pKi	328	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	In vitro binding affinity at human Alpha-1D adrenergic receptor.	B	8.2	pKi	6.3	nM	Ki	J Med Chem (2003) 46: 2877-2894 [PMID:12825930]
ChEMBL	Binding affinity for human Alpha-1D adrenergic receptor	B	8.8	pKi	1.6	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	Compound was tested for its binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergic receptor (n >= 2)	B	8.8	pKi	1.6	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
ChEMBL	Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor	B	8.84	pKi	1.45	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Displacement of [3H]prazosin from human Alpha-1D adrenergic receptor expressed in CHO cells	B	8.89	pKi	1.29	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Displacement [3H]prazosin of human recombinant Alpha-1D adrenergic receptor expressed in CHO cells by rapid filtration technique	B	8.89	pKi	1.29	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]prazosin from human recombinant Alpha-1D adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Displacement of [3H]prazosin from recombinant human alpha1d adrenergic receptor expressed in CHO cell membranes after 30 mins by TopCount liquid scintillation counting method	B	8.89	pKi	1.29	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]Prazosin from human recombinant alpha 1D adrenergic receptor expressed in CHO cells incubated for 30 mins by radioligand competition binding assay	B	8.89	pKi	1.29	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Binding affinity at human cloned Alpha-1D adrenergic receptor in chinese hamster ovary cells by [3H]prazosin displacement.	B	8.89	pKi	1.29	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells	B	8.89	pKi	1.29	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
GtoPdb	-	-	9.1	pKi	-	-	-	Jpn J Pharmacol (2001) 86: 189-95 [PMID:11459121]; Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
ChEMBL	Binding affinity towards human Alpha-1D adrenergic receptor	B	9.11	pKi	0.78	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL	In vitro functional activity at Alpha-1D adrenergic receptor in rat aorta	B	8.22	pKd	6.03	nM	Kd	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
ChEMBL	Antagonism of norepinephrine induced contraction of rat isolated thoracic aorta.	F	8.34	pKd	4.57	nM	Kd	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor	F	8.4	pKd	3.98	nM	Kd	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL	Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr	F	8.52	pKd	3.02	nM	Kd	Eur J Med Chem (2011) 46: 3000-3012 [PMID:21549456]
ChEMBL	Binding affinity to the adrenergic receptor alpha-1D of rat aorta	B	8.07	pKi	8.6	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Compound was evaluated for its ability to displace [125I]HEAT binding from rat Alpha-1D adrenergic receptor	B	8.62	pKi	2.4	nM	Ki	J Med Chem (1998) 41: 1205-1208 [PMID:9548811]
GtoPdb	-	-	9	pKi	-	-	-	Bioorg Med Chem Lett (2001) 11: 1119-21 [PMID:11354357]
ChEMBL	Binding affinity towards rat Alpha-1D adrenergic receptor	B	9.02	pKi	0.96	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1119-1121 [PMID:11354357]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity for human Dopamine receptor D2	B	7.85	pKi	14	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Displacement of [3H]spiperone from rat brain Dopamine receptor D2	B	7.31	pKi	48.98	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Binding affinity at native Dopamine receptor D2 in rat striatum by [3H]spiperone displacement.	B	7.32	pKi	47.86	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	In vitro binding affinity towards Dopamine receptor D2 in rat striatum was determined using [3H]-spiperone as radioligand	B	7.76	pKi	17.38	nM	Ki	J Med Chem (1995) 38: 4044-4055 [PMID:7562940]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL	Binding affinity for rat Dopamine receptor D3	B	8.51	pKi	3.1	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity at human cloned 5-hydroxytryptamine 1A receptor expressed in HeLa cells by [3H]8-hydroxy-2-(di-n-propylamino)tetraline displacement.	B	8.76	pKi	1.74	nM	Ki	J Med Chem (1998) 41: 4844-4853 [PMID:9822553]
ChEMBL	Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in human HeLa cells	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2017-2020 [PMID:20185311]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HeLa cell membranes after 30 mins by TopCount liquid scintillation counting method	B	8.9	pKi	1.26	nM	Ki	Eur J Med Chem (2017) 125: 435-452 [PMID:27689727]
ChEMBL	Displacement of [3H]-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cells after 30 mins by liquid scintillation counting	B	8.9	pKi	1.26	nM	Ki	J Med Chem (2012) 55: 23-36 [PMID:22145629]
ChEMBL	Inhibitory constant value against the 5-hydroxytryptamine 1A receptor	B	8.9	pKi	1.26	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1185-1188 [PMID:15686938]
ChEMBL	Displacement [3H]8-OH-DPAT of human cloned 5HT1A receptor expressed in human HeLa cells by rapid filtration technique	B	8.9	pKi	1.26	nM	Ki	Eur J Med Chem (2010) 45: 3740-3751 [PMID:20605276]
ChEMBL	Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptor	B	9.03	pKi	0.93	nM	Ki	J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL	Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]8-OH-DPAT) as radioligand	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2004) 47: 1900-1918 [PMID:15055991]
ChEMBL	Binding affinity for human 5-hydroxytryptamine 1A receptor	B	9.34	pKi	0.46	nM	Ki	J Med Chem (2005) 48: 3076-3079 [PMID:15828846]
ChEMBL	Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in human HeLa cells	B	9.43	pKi	0.37	nM	Ki	J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL	Displacement of [3H]8-OH-DPAT from recombinant human 5HT1A receptor expressed in human HeLa cell membranes after 30 mins by liquid scintillation counting method	B	9.43	pKi	0.37	nM	Ki	Eur J Med Chem (2017) 125: 233-244 [PMID:27662034]
ChEMBL	Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in human HeLa cells incubated for 30 mins by radioligand competition binding assay	B	9.43	pKi	0.37	nM	Ki	Eur J Med Chem (2019) 168: 461-473 [PMID:30844609]
ChEMBL	Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cell membranes after 30 mins	B	9.43	pKi	0.37	nM	Ki	J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL	Affinity constant on CHO cells expressing Human recombinant 5-hydroxytryptamine receptor 1A	B	9.43	pKi	0.37	nM	Ki	J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
GtoPdb	-	-	8	pIC50	-	-	-	Life Sci (1997) 60: 653-65 [PMID:9048968]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement	B	7.1	pKi	79.43	nM	Ki	J Med Chem (1996) 39: 126-134 [PMID:8568799]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1A receptor in the rat brain (hippocampus) using [3H]8-OH-DPAT	B	8.09	pKi	8.2	nM	Ki	J Med Chem (1996) 39: 1125-1129 [PMID:8676348]
ChEMBL	Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement	B	8.62	pKi	2.4	nM	Ki	J Med Chem (1996) 39: 126-134 [PMID:8568799]
ChEMBL	Binding affinity at 5-hydroxytryptamine 1A receptor	B	8.71	pKi	1.95	nM	Ki	J Med Chem (1995) 38: 4044-4055 [PMID:7562940]
ChEMBL	Compound was evaluated for its ability to displace [3H]8-OH-DPAT from serotonin 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes	B	8.62	pIC50	2.4	nM	IC50	Bioorg Med Chem Lett (1996) 6: 689-694
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL	Binding affinity at 5-hydroxytryptamine 1B receptor	B	5	pKi	>10000	nM	Ki	J Med Chem (1995) 38: 4044-4055 [PMID:7562940]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]